Polynucleotide Treatment in London
Doctor-led polynucleotide injections in Kensington, aimed at improving skin quality, fine lines and tired-looking under-eyes, without adding volume.
Free consultation · Doctor-led · From £250 · Kensington W8
- Over a decade of clinical experience
- Doctor-led care
★★★★★ 5.0 Google rating · 22 reviews
Treatment at a glance
Treatment time
30–45 minutes
Recommended course
3 sessions, 3–4 weeks apart
Downtime
Redness or small bumps for 24–48 hours
Results
Gradual, from around 3 weeks
Results may last
6–9 months (manufacturer guidance)
Price
From £250 · courses from £675
Consultation
Free, with Dr Gregorio
What are polynucleotides?
Polynucleotides (PN) are purified fragments of DNA, usually sourced from salmon or trout, prepared as a sterile injectable gel. They are often grouped with skin boosters. At Vitalumina, every treatment is planned and performed by Dr Gregorio De Carvalho.
How they work. Placed in the skin with fine injections, polynucleotides are designed to support the skin’s own repair processes, hydration and elasticity. They do not add volume or change your features, so any change is subtle and develops over several weeks.
What the evidence says. Early clinical studies report improvements in skin quality, but the research is still limited and results vary between patients. Dr Gregorio will explain what is realistic for your skin before you decide.
The polynucleotide products we use
LUMI EYES & NUCLEOFILL
Lighter formulations for the thin, delicate skin under the eyes, often chosen for dark circles, crepey texture and fine lines.
NEWEST
Polynucleotides combined with hyaluronic acid, used on the face and neck for dull, dehydrated or tired-looking skin.
PLENHYAGE XL
A higher-concentration polynucleotide gel for more weathered skin, and as part of a combined plan for acne scarring.
All are CE-marked medical devices, and the product is chosen for the area and your skin at consultation. We also offer Rejuran, a well-known polynucleotide brand. If hydration is the main goal, Profhilo and skin boosters may suit you better; for deeper firmness, collagen stimulation.
TREATMENT OVERVIEW
Polynucleotide treatment cost
From £250 per session, with courses of 3 sessions from £675. Your consultation is free.
Treatment time
30–45 minutes
Downtime
Redness or small bumps for 24–48 hours
Results visible
Gradual, from around 3 weeks
Maintenance
Every 6–9 months
Anaesthetic
Numbing cream
Course
Usually 3 sessions, 3–4 weeks apart
Areas
Under-eyes, face, neck, décolletage
Potential benefits
May help with skin texture, hydration and fine lines, especially around the eyes and neck. No added volume.
Limitations
Change is gradual and varies between people. Polynucleotides do not lift sagging skin or replace lost volume.
Prices
Polynucleotide treatment prices
Clear pricing, a free doctor-led consultation, and no obligation to go ahead.
Under-eyes
Lumi Eyes or Nucleofill Eyes
Course of 3 sessions
£675
£225 per session · save £75 vs single sessions
Single session: £250
Book my free consultationFace & neck
Newest or Nucleofill
Course of 3 sessions
£795
£265 per session · save £90 vs single sessions
Single session: £295
Book my free consultationAdvanced skin renewal
Plenhyage XL
Course of 3 sessions
£875
approx. £292 per session · save £100 vs single sessions
Single session: £325
Book my free consultationFree consultation with Dr Gregorio · Doctor-led treatment · CE-marked products · 237 Kensington High Street
The final price is confirmed at your consultation, based on the product, treatment area and individual plan. A course of 3 sessions, 3–4 weeks apart, is usually recommended, which is why it is shown as the recommended option.
Why Vitalumina
Why choose Dr Gregorio for polynucleotides
Doctor-led, start to finish
Every treatment is assessed, performed and reviewed by Dr Gregorio De Carvalho — the same doctor at every step.
Over a decade of experience
An internationally trained medical doctor with a Master’s in Aesthetic & Anti-Ageing Medicine.
Free, no-obligation consultation
Honest advice first. Sometimes the right recommendation is less treatment, or none.
CE-marked products
Established polynucleotide brands, chosen for the area and your skin.
Clear pricing
From £250 per session, with courses of 3 from £675. Confirmed at consultation.
Kensington High Street
237 Kensington High Street, W8 6SA, near High Street Kensington station.
Most requested
Polynucleotides for under-eyes in London
The skin under the eyes is thin and shows tiredness early: dark circles, crepey texture and fine lines. Polynucleotide under-eye treatment uses lighter formulations, such as Lumi Eyes or Nucleofill Eyes, placed with fine injections to support skin quality without adding volume.
It is often considered when the concern is skin quality rather than hollowness. Where volume loss is the main issue, Dr Gregorio will explain other options honestly at your consultation.
Ask about under-eye treatment →- Course: usually 3 sessions, 3–4 weeks apart
- Session: 30–45 minutes, with numbing cream
- Afterwards: small bumps or redness for 24–48 hours
- Price: from £250 per session · course of 3: £675
- Results: gradual and vary between people
What our patients say.
Dr. José Gregorio is truly exceptional. I trust him with my face like no one else, and that says it all. His expertise, precision, and aesthetic eye are outstanding. Every procedure leaves me looking refreshed, natural, and confident.
Dr. José Gregorio is truly exceptional. I trust him completely with my face. His skill, precision, and strong aesthetic eye are outstanding. The results are always natural, balanced, and never overdone.
Dr. Gregorio is a highly qualified professional with an excellent eye for achieving natural aesthetic results. He is experienced and offers a full range of aesthetic treatments, including advanced facial rejuvenation options.
I had an excellent skincare consultation and treatment with Dr. Gregorio. He was thorough, attentive, and took the time to tailor the treatment to my skin’s needs. I felt very well looked after from start to finish and noticed a clear improvement.
An excellent experience from start to finish. From the very beginning, the staff were kind and professional, always attentive to every detail. The facilities are spotless, modern, and inspire complete confidence.
I had several procedures done with Dr. Gregorio and I loved the results. His work is very professional and successful. Based on my own experience, I highly recommend him.
I have had the opportunity to use Dr. Gregorio’s services and he is truly very professional in his work. He always meets my expectations and helps me feel my best.
A very competent doctor with extensive experience. I highly recommend him for his excellent clinical results.
I have known Dr. Gregorio for more than 10 years and I have always been very satisfied with the results of every procedure he has performed on me. His work is consistently professional, thoughtful, and reliable.
I loved Dr. Gregório’s work and highly recommend him.
The best doctor in Ontario!
Five-star experience.
I have been a patient of Dr. Gregorio for more than 10 years and I can confidently say my experience has been exceptional. From the first appointment, he made me feel comfortable and valued, always taking the time to understand my needs.
Excellent experience.
Excellent experience.
Polynucleotide Treatment Areas
Polynucleotides treat skin quality rather than structure. These are the areas most often discussed at consultation.
Under-Eyes
Polynucleotide under-eye treatment is the most requested: for dark circles, crepey skin and fine lines around the eyes.
Face
Dull, dehydrated or tired-looking skin, fine lines and uneven texture across the face.
Neck & Décolletage
Crepey skin and horizontal neck lines on the neck and décolletage, areas that are often overlooked.
Acne Scarring
Shallow acne scarring, as part of a combined plan depending on the type of scar.
Skin Rejuvenation
Polynucleotide skin rejuvenation for early signs of ageing, where the aim is healthier-looking skin rather than a different look.
Not a Filler
Polynucleotides do not add volume or change your features. Where volume or structure is the concern, Dr Gregorio will discuss other options such as dermal fillers or collagen stimulation.
Your Treatment Journey
From consultation to maintenance, every step is with the same doctor. Most people return to normal activities the same day.
Week 0 free consultation and first session · Weeks 3–8 sessions 2 and 3; some patients notice smoother, brighter-looking skin from around 3 weeks · After the course changes may continue to develop; a maintenance session every 6–9 months may be recommended.
Free Consultation
Dr Gregorio reviews your concerns, medical history and skin, explains realistic outcomes and confirms whether polynucleotides are suitable. There is no obligation to go ahead.
Treatment Sessions
Numbing cream is applied, then the product is placed with fine injections. Each session takes 30–45 minutes. A typical course is 3 sessions, 3–4 weeks apart.
Results & Maintenance
Any changes build gradually, sometimes from around 3 weeks after the first session, and may continue through the course. A maintenance session every 6–9 months may be recommended. Results vary.
Safety, Suitability and Aftercare
Polynucleotides are generally well tolerated when given by a trained medical professional. As with any injectable treatment there are risks, and these are discussed at your consultation.
Side Effects
Redness, swelling, tenderness and small bumps at the injection points are common and usually settle within 24–48 hours. Bruising can occur. Infection and allergic reactions are rare.
Not Suitable If
You are pregnant or breastfeeding, have a fish or polynucleotide allergy, or have active infection or inflammation in the area. Some medical conditions and medicines need review first.
Aftercare
Avoid make-up for 12 hours, and strenuous exercise, saunas and alcohol for 24 hours. Do not massage the area, and use daily SPF. Contact the clinic if anything concerns you.
Clinical evidence
Clinical evidence & references
Polynucleotides are a developing area. The evidence so far is encouraging but limited, and results vary between people.
- Lee YJ, Kim HT, Lee YJ, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. J Dermatolog Treat. 2022;33(1):254–260. doi:10.1080/09546634.2020.1748857A 27-patient randomised split-face trial found polynucleotide injections effective and safe for the under-eye area.
- Cavallini M, Bartoletti E, Maioli L, et al. Consensus report on the use of PN-HPT (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021;20(3):922–928. doi:10.1111/jocd.13679An expert consensus (eight clinicians) describing how purified polynucleotides are used for skin revitalisation.
- Lampridou S, Bassett S, Cavallini M, Christopoulos G. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmet Dermatol. 2025;24(2):e16721. doi:10.1111/jocd.16721A review of nine studies (219 patients) concluding polynucleotides are promising but more high-quality studies are needed.
Polynucleotide treatment in London: frequently asked questions
How much does polynucleotide treatment cost in London?
At Vitalumina, polynucleotide treatment is from £250 per session for the under-eyes, £295 for the face and neck, and £325 for advanced skin renewal with Plenhyage XL. A course of 3 sessions is £675, £795 or £875 respectively. Your consultation is free, and the final price is confirmed at consultation, based on the product, treatment area and individual treatment plan.
How many sessions will I need?
Most people have a course of 3 sessions, 3–4 weeks apart; some benefit from a fourth. A maintenance session every 6–9 months is often recommended.
When will I see results?
Changes are gradual. Some patients notice brighter, smoother-looking skin from around 3 weeks after the first session, with further change through the course. Results vary, and some people see little difference.
How long do polynucleotide results last?
Manufacturers suggest results typically last around 6–9 months after a full course, depending on your skin, age and lifestyle. Maintenance sessions can help to keep them.
Do polynucleotide injections hurt?
Numbing cream is applied first. Most patients describe mild, brief discomfort during the injections.
What are the side effects?
Redness, swelling and small bumps at the injection points are common and usually settle within 24–48 hours. Bruising can occur. Serious complications are rare and are discussed at your consultation.
Who should not have polynucleotides?
They are not suitable during pregnancy or breastfeeding, with a known fish or polynucleotide allergy, or with active infection or inflammation in the area. Dr Gregorio checks your medical history before any treatment.
Polynucleotides or Profhilo: which is better?
Both work on skin quality. Profhilo is hyaluronic acid and mainly hydrates; polynucleotides are designed to support skin repair and are often chosen for the under-eyes. Some patients benefit from both, and Dr Gregorio will advise at consultation.
Where is the clinic?
Vitalumina is at 237 Kensington High Street, London W8 6SA, near High Street Kensington station. Appointments are by arrangement; message us on WhatsApp to check availability.
Are polynucleotides worth it?
For many people looking for subtle, natural-looking improvement in skin quality, especially around the eyes and neck, polynucleotides can be a good option. The evidence is encouraging but still limited, results vary, and a course is usually needed. Dr Gregorio will tell you honestly at your free consultation whether they are likely to help you, or whether another option would suit you better.
Are polynucleotides the same as fillers?
No. Fillers add volume to restore shape or structure. Polynucleotides do not add volume; they are designed to support skin quality, hydration and elasticity, so the change is gradual and subtle.
Are polynucleotides better than anti-wrinkle injections?
They do different jobs. Anti-wrinkle injections relax the muscles that cause expression lines, while polynucleotides work on the quality of the skin itself. Some patients benefit from both; Dr Gregorio will recommend what suits your concerns at consultation.
Your doctor
Who performs your treatment
Every polynucleotide treatment at Vitalumina is assessed and performed by Dr Gregorio De Carvalho, an internationally trained medical doctor with a Master’s in Aesthetic & Anti-Ageing Medicine and over a decade of experience in aesthetic medicine. More about your aesthetic doctor in Kensington.
Polynucleotide treatment in Kensington: Vitalumina, 237 Kensington High Street, London W8 6SA, near High Street Kensington station. Appointments by arrangement. Get directions.
Book your free consultation on WhatsApp →Ready to talk it through?
Book your free consultation with Dr Gregorio in Kensington.